Along the line of being prepared, when we first bought our used TV, we had a 26S and got a blow out on the left rear tire while travelling through Ohio, on the Interstate, temperature 34 C. Before leaving home I had looked at the tires and they were still in good shape and I reviewed the tire changing scenario in the manual. The first issue was the lug nut anti theft adapter, found it, next the lowering of the spare. GM has a secondary safety catch that stops the spare from going lower than 6", if it doesn't release then you have to use the wheel chocks provided to support the bottle jack and then jack the spare up until it releases. That took 5 tries.
Ok, got it off and put the spare on. No replacement to be found, drove through to Nashville on the spare. I bought 4 new tires at Costco in Nashville. The anti theft lug nut adapter stripped and they couldn't get 2 of the wheels off. We spent a day and a half trying to get that done while driving with 2 new and 2 old tires on. Finally after going to the GM and the Chev dealerships across the street from each other in Nashville, their service people couldn't do it and then they closed for the day. We found Carl Black Chev Olds the next morning and they did it in 5 minutes charging an hour for labour. We were just happy to have it done. So the first thing I did was get rid of the anti theft nuts.
When the spare was returned to the underside of the bed it would not lock so I had to check it periodically to make sure it didn't lower on its own. Two years later I tried to remove the spare again to replace it. I tried 15 times in my own lane way and couldn't do it. I had to have it done where I go for service. They had a lot of trouble getting it off. Now I carry the spare locked in the box with a wire rope. If you have a GM then check the spare lowering system, lubricate and maintain it. The replacement part is not cheap.
I also carry a bunch of "just in case" tools and a compressor.
Married To The Navigator
2005 Red GMC Duramax 4X4 HD Crew Cab
4" Magnaflow, Banks Air Intake
Firestone Ride Rite Air Springs