If we're talking about a lot of mice potentially, I'd be concerned about more than the mattress. All I can think of is to take the mattress out and bring it home and Buy a few boxes of mouse bait. I'd probably do both. If I were to find one mouse turd on my bed I'd probably throw the bed away, but I'm a little weird when it comes to that stuff.
2016 27BHS Elite
2012 F-150 EcoBoost / Max Tow