Risk versus reward. I might leave it on if I have a 12 hour drive ahead of me with food in the fridge. On the other hand a two hour drive to the lake, I wouldn't.
With a little pre-planning and pre-cooling of the fridge, you can minimize the number of times you need to run with your propane on. Life's about risk management.
2013 Ram Longhorn 3500 Crew Cab 6.7 Turbo Diesel, Aisin Transmission.
2014 Jayco Eagle Premier 351 RSTS, Mor/Ryde Suspension and Pin Box, 17.5" wheel upgrade, 18k Pull Rite hitch.