One thing I've only seen mentioned once in this discussion is SPEED
Even the best, most expensive tire will fail if the speed rating is exceeded for long periods of time. Particularly if the tire is under inflated!
IMHO, it's the #1 reason for tread separation.
I have people passing me all the time pulling utility trailers, boat trailers, pop ups, travel trailers, fifth wheels, and all classes of motor homes doing 70 - 85 mph
. If your tires are rated for higher speeds, go for it. But if you're like most of us, your tires are rated for max. operating speed of 65 mph. Do your family a favor, and don't drive faster than the speed at which your tires are rated. In addition, most states I travel though have a max. speed for RV's that is the same as the max. truck speed. Why would you want to both break the law and endanger your family?
To quote Louis L'Amour, "Take your time; you'll get a more harmonious outcome!"