I have the 2015 X213 and tow with an 2013 F150.
I have not replaced the bathroom fan. For my family the stock fan works well enough.
As for the tailgate. I can't fully open my tailgate when hooked up. It really hasn't been a problem for me. I do have a folding tonneau cover and can access what's in the bed that way.
In all honesty I love the combo. The F150 is a full crew cab with the Ecoboost and tows great. The X213 is a perfect size trailer for our family with a great floor plan, perfect amenities, and is a smooth tow behind the F150 with an Equalizer WDH.
'13 Ford F 150, FX4 Off Road, Ecoboost
'15 Jayco Jay Feather X213 BH