I towed many miles with a 2003 Ram 2500 Quad cab 4x4 and it pulls very well. It also drinks fuel like it's water. I averaged 8 to 8.5 but I didn't baby it either. I wouldn't have gotten rid of it except the dealer offered me $10k trade in June so I jumped on it! I figured the truck wasn't worth that selling outright.
The only serious issue I had with mine was the steering. I had a couple different alignments, steering boxes and eventually needed new ball joints (second time in 20k miles) to keep it from wandering all over the road. This cost me over $1500 and that was without u-joints or wheel bearings. With that said, check the steering and handling very carefully. If you can hook the trailer up to it for a test drive, I would highly recommend doing so just to see how it handles. Mine was all over the road.
2017 28BHBE Kitchen skylight, remote control and Aluminum wheels hitched by ProPride 3P
2012 Jayco Jay Flight 26BH traded in
2013 Toyota Tundra DC 4x4, 5.7, 6 speed 4.30 gears