I don't see why there would be any issues whatsoever. The critical components of a tow vehicle are primarily drive train. The body style has little if anything to do with it. Frankly, I'm surprised at how few vans are used as tow vehicles.
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2006 23B Hybrid with 10k round bar WDH
2011 F150 4x4 SCREW Ecoboost, Max Tow, Integrated TBC, 3.73 LS axle, Firestone Ride Rite airbags.
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