I do only if camping for longer periods in the summer (hot) without hookups, or during a really long period of storage, but thats about it.
What I do to prevent smells is that I have a clear section between the "stinky slinky" and the TT, and use a Tornado tank flusher, and I make sure the tanks are "truly" empty - sometimes even after it looks like it's all out, and then I close the tank, run the Tornado for a bit and open it up I can see "leftovers" sneaking out.
2012 Jayco 32TSBH
2004 Ford Excursion
ProPride 3P / Tru Control brake controller
Roadmaster Active Suspension