Our only trip to MB, we did 81, 66, 17, 95. Mostly a good route, but too much on I95.
Our preferred route to the South keeps on 81 much farther. I would suggest staying on to Roanoke, then heading down 220 and 70 straight into Myrtle. 220 is a State Highway, so there will be stops, but it is twinned the whole way. I don't know this specific route through Roanoke, but we travel to Hilton Head and Florida on a similar route taking 77 down through Charlotte.
None of those highways is as much a freakshow as on I-95. I much prefer the relaxed pace and traffic on 81.
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2011 Jayco X19H (purchased 2015)
2008 Jayco 1007 PUP (purchased new, traded for the X19)
2018 Nissan Titan Midnight Ed.
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