As far as driving handling goes, it is hard to get much better than a properly setup 5th wheel. However, I base that on what I have owned and I highly suspect that the largest of the 5th wheels especially with a truck that isn't rated much higher than the 5th wheel's weight would handle differently not too mention the hitch setup where an air ride hitch would be a smoother ride than a standard 5th wheel hitch.
Also to consider, there are only three Class C chassis to choose from with most being the Ford E series, but for a Class A you have even more choices such as Ford F53, Freightliner, Spartan, some with rear engines, some with front engines, and many with their own set of features as well as issues. Point being is that you can't really compare the handling simply based on Class A or Class C as you need to compare based on the chassis manufacture, chassis make\model, engine sizes, motorhome weight, length, and similar differences and even then different model motorhomes would still likely handle differently due to the weight distribution (some reports are that one side is a lot heavier than the other side for example). ~CA
2010 GreyHawk 31SS