You have the new V12 model hehe
. A newer MH will be like driving a newer car.
#1 key; keep your MH well maintained. Next think about how to keep your engine cool. Try not to apply any excess loads on the engine. Keep an eye on your temperature gauge, slow down if you need to, aka back off on the throttle if needed. If possible drive during the cooler parts of the day.
Another big item to remove any excess load(s) from the engine is the engine AC unit. Do not use it if your engine temp is elevated. Run your generator for AC. If needed have one or two (120V) small clip on fans to aim some cool air your way.
One thing I always do at least once a year. I hose off the radiator (don't use a power washer). This removes the excess dirt, bugs, etc, so it can operate more efficiently.
Have a fun trip!