Personally I can't see why the main tank would need to be shut off. You would be feeding into the low pressure side of the system and the tank is on the high pressure side. How could low pressure mess with a much higher pressure.
Don't know if it would freak out the regulator but probably not. I have thought about doing the same thing with my low pressure fitting mainly because I am lazy and was looking for alternatives to filling up my tank. Currently my SeeLevelII gauge shows 45% full and I am going on a 4 day trip next week. If I don't fill up the tank I will end up watching my gauge the entire trip.
Talked myself into filling the tank tomorrow. Jeeze being old and lazy sucks. My propane filler is only 1 mile from my house and a great place to go to. I am pathetic.