Are you talking headlamps?
The Ford E-series only came with Halogens, and the reflectors are not designed for LED. Putting LED bulbs in an assembly designed for halogen creates potentially unsafe glare for oncoming traffic. You may not care, but, I'm just explaining that there is a consideration there. If forward lighting isn't optimal with stock bulbs, I'd suggest adding an aftermarket set of LED fog lamps (not marked for 'off road use only'). Those WILL be designed to focus and/or disperse light appropriately and will vastly improve your night vision.
If you're talking about HOUSE bulbs and the like, I usually just google the number on the bulb and find an LED equivalent. Then, buy a few extras if they are fairly cheap....sometimes matching color temperature can be tough with so many manufacturers and colors of LED bulbs, and if one goes out, you don't want to have mismatched colors and have to replace them all.
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