Not in that large a FW but we manage full time in ours.
The big issue is getting rid of stuff you don't need. Clothes for the wife was a big one. Tools for me.
Hobbies to keep busy is the big one. We got a bunkhouse for that reason. The bunkhouse was converted to our hobby room. Photography, sewing, weaving, etc for her. Shooting, model airplanes and fishing for me.
Two things the wife misses a lot. Laundry room (full size washer/dryer). Decorating. She would redecorate our 2700sqft house. About once a month she would change a room in the house. An RV leaves very little leeway for that kind of stuff. Not much wall space to hang stuff, not much counter/table space to display stuff. Small couch so not much room for pillows/throws. Can't rearrange furniture. She is adapting