First off welcome. What 5th wheel do you have? If you go by what the manufacture says, can't quote chapter and verse, but they do not recommend having the wheels not contacting the ground when leveling. In an unlevel spot I try to get it as level as possible, size to side, by putting boards under the low side wheels. As a result you will likely have to put blocks under the jacks or you'll receive an error message for out of stroke as it tries to level. That's been my experience and my input to answer your question.
Keith and Lisa Ward
2019 Pinnacle 36FBTS
2021 Ford F350 XLT CC LB DRW 6.7L Diesel
Demco 18K Autoslide Hitch
2019 Ford F350 SB 6.7L Diesel (Gone)