Yes. We virtually always tow with ~80gal of fresh water with no problems. The few times we didn't have full tanks, I didn't notice any difference.
Sherm & Terry w/rescue Eydie (min Schnauzer) & Charley (std Poodle)
2015 Jay Flight 27RLS, GY Endurance (E), Days: 102 '15, 90 '16, 80 '17, 161 '18
2006 Ford F350 PSD, 4WD, CC, LB, SRW, Cmpr. pkg, Equal-i-zer 4-p, Continental ContiTrac TR