I always fine tune after the slides are out. The my two slides are on the same side and tend to tilt the trailer that way. Also the jacks sink a bit. I auto level, put slides out and fine tune as needed with manual adjustments. I monitor the levelness and adjust as needed daily. Typically only needed once. Depends how soft the ground is.
2017 Eagle 293RKDS, factory ordered, lots of mods and upgrades. More than I can list.
2018 Ram 3500 crew cab long bed SRW diesel 6spd Aisin 4wd Tradesman.
B&W Ram puck 5th wheel
Mopar wheel to wheel steps