No issues at all with the F-450. It's pretty much the same as the 350 as far as bed and bumper clearances.
The only thing I would suggest, as other have already, is to watch the tailgate when hitching up. I keep mine down/open when hitching but it does get close. Make sure you stay fairly straight when hooking up.
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2020 Dynamax DX3 Super C
SOLD - 2017 Ford F-450 KR Ultimate, Bronze Fire
SOLD - 2017 Jayco North Point 377RLBH
USAF Retired / 1988-2012
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