I don't see why there would be any issues whatsoever. The critical components of a tow vehicle are primarily drive train. The body style has little if anything to do with it. Frankly, I'm surprised at how few vans are used as tow vehicles.
2006 23B Hybrid with 10k round bar WDH
2011 F150 4x4 SCREW Ecoboost, Max Tow, Integrated TBC, 3.73 LS axle, Firestone Ride Rite airbags.