Been struggling to figure this out as well recently. It's not an easy thing to simply look up. FWIW, this is what I've found on one website, and I think the critical things to note appear to be for the E450 with 16" wheels as follows. I'm going to where I store it to check and confirm if its the four hole wheel.
16 x 6 inch
8 lugs
bolt pattern: 6.5 inch
Take from website:
https://www.hubcaphaven.com/p/8063/s...8c2z1015g.html
Make/Model/Year:
Ford E-350 DRW 2007-2018
Ford E-450 DRW 2007-2018
Product Specifications:
Product ID: STL3872U
Product: Wheel/Rim
Material: Steel
Style: 4 Hole
Finish: Powder Coat Grey or White
Size: 16x6
Lugs: 8
Bolt Pattern: 6.5 Inch
Indents: 8C241015GA, 8C241015HA
OE Part Number: 8C2Z1015G
Hope it helps...