MA offers a variety of specialty plates, and I got my Pan Mass Challenge (supports cancer research at Dana Farber Cancer Institute) plates last week. Yes they are a little more expensive, but all of the money goes to a good cause so IMHO it's worth it.
DW got the same randomly assigned unique plate others have mentioned about 30 years ago, but refuses to change it as it just happened to have her initials on it.
Rob & Kelly, Bella & Brady (Miniature Schnauzers)
2016 Eagle 323LKTS
2016 Ram 2500 6.7L CTD
2015 White Hawk 29REKS Summit Edition (Traded)